Application of mammalian cytogenetics to mutagenicity studies. [Triethylone melamine, x radiation, gamma radiation, LET]
Conference
·
OSTI ID:7211824
Studies on induction of chromosome damage in germ cells by triethylene melamine (TEM) included determination of frequencies of chromosomal aberrations observed in human leukocytes after treating different stages of the cell cycle with TEM, frequencies of chromatid aberrations in metaphase I oocytes and the female pronuclear chromosomes following treatment of female mice with TEM, and frequencies of labeled diplotene-diakinesis figures and chromosome abberations at various intervals after treatment of primary spermatocytes with TEM and /sup 3/H-thymidine. Studies on effects of low linear energy transfer radiation on mouse oocytes showed that the frequency of aberrations increased as a function of time and remained constant 8 to 9 days post-exposure. It was concluded that cytogenetic procedures were adequate to evaluate certain mutagenic end points. (HLW)
- Research Organization:
- Oak Ridge National Lab., Tenn. (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 7211824
- Report Number(s):
- CONF-770718-4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMALS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CYTOLOGICAL TECHNIQUES
DRUGS
ELECTROMAGNETIC RADIATION
ENERGY TRANSFER
GAMMA RADIATION
GERM CELLS
HYDROGEN ISOTOPES
IONIZING RADIATIONS
ISOTOPE APPLICATIONS
ISOTOPES
LET
LEUKOCYTES
LIGHT NUCLEI
MAMMALS
MAN
MICE
MUTAGENESIS
MUTATIONS
NUCLEI
ODD-EVEN NUCLEI
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SPERMATOCYTES
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMALS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CYTOLOGICAL TECHNIQUES
DRUGS
ELECTROMAGNETIC RADIATION
ENERGY TRANSFER
GAMMA RADIATION
GERM CELLS
HYDROGEN ISOTOPES
IONIZING RADIATIONS
ISOTOPE APPLICATIONS
ISOTOPES
LET
LEUKOCYTES
LIGHT NUCLEI
MAMMALS
MAN
MICE
MUTAGENESIS
MUTATIONS
NUCLEI
ODD-EVEN NUCLEI
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SPERMATOCYTES
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES