Cytogenetic analysis of mouse metaphase II oocytes following exposure to tritiated water
Journal Article
·
· Radiat. Res.; (United States)
Female mice were given different dosages (0, 3.0, 7.5, 15.0, or 30 muCi/ml) of tritium in their drinking water continuously from 3 to 7 weeks of age to assess the effects on germ cell chromosomes. At 8-9 weeks of age, mice were superovulated and metaphase II oocytes were processed and C-banded for cytogenetic analyses. Chromatid acentric fragments were the only type of structural aberration detected, and their incidence was higher in controls than in any of the tritiated water (HTO) groups. Analysis of numerical chromosomal aberrations revealed that the incidence of hypoploid (N = 19) oocytes was higher in oocytes from mice who drank HTO as compared with controls. However, the effects of HTO upon aneuploidy induction was not definitive due to the increase the incidence of aberrations in mouse oocytes can be related to the low dose rate resulting from chronic HTO exposure and possibly death of tritium-damaged cells.
- Research Organization:
- Louisiana State Univ. Medical Center, Shreveport
- OSTI ID:
- 5845683
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 111:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Application of mammalian cytogenetics to mutagenicity studies. [Triethylone melamine, x radiation, gamma radiation, LET]
Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice
Human sperm chromosomes. Long-term effect of cancer treatment
Conference
·
Fri Dec 31 23:00:00 EST 1976
·
OSTI ID:7211824
Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice
Journal Article
·
Wed Jun 24 00:00:00 EDT 2009
· Proceedings of the National Academy of Sciences USA
·
OSTI ID:974252
Human sperm chromosomes. Long-term effect of cancer treatment
Journal Article
·
Fri Jun 01 00:00:00 EDT 1990
· Cancer Genetics and Cytogenetics; (USA)
·
OSTI ID:6748895
Related Subjects
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL DIVISION
CHROMOSOMAL ABERRATIONS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GERM CELLS
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEIOSIS
MICE
MUTAGENESIS
MUTATIONS
NUCLEI
ODD-EVEN NUCLEI
OOCYTES
OVULATION
OXYGEN COMPOUNDS
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
TRITIUM
VERTEBRATES
WATER
YEARS LIVING RADIOISOTOPES
Kinetics
& Toxicology-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL DIVISION
CHROMOSOMAL ABERRATIONS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GERM CELLS
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEIOSIS
MICE
MUTAGENESIS
MUTATIONS
NUCLEI
ODD-EVEN NUCLEI
OOCYTES
OVULATION
OXYGEN COMPOUNDS
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
TRITIUM
VERTEBRATES
WATER
YEARS LIVING RADIOISOTOPES