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Title: Human sperm chromosomes. Long-term effect of cancer treatment

Abstract

The long-term cytogenetic effect of radio- or chemotherapy or both on male germ cells was evaluated by study of the chromosomal abnormalities in spermatozoa of four men treated for cancer 5-18 years earlier. The cytogenetic analysis of 422 sperm metaphases showed no differences in the aneuploidy rate. The incidence of structural chromosome aberrations was 14.0%, however, which is much higher than in controls. Thus, the high incidence of structurally aberrant spermatozoa observed in our long-term study indicates that antitumoral treatments affect stem-cell spermatogonia and that aberrant cells can survive germinal selection and produce abnormal spermatozoa.

Authors:
; ; ; ; ;  [1]
  1. (Universitat Autonoma de Barcelona (Spain))
Publication Date:
OSTI Identifier:
6748895
Alternate Identifier(s):
OSTI ID: 6748895
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cancer Genetics and Cytogenetics; (USA); Journal Volume: 46:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHROMOSOMAL ABERRATIONS; RADIOINDUCTION; RADIOTHERAPY; SIDE EFFECTS; SPERMATOZOA; BIOLOGICAL RADIATION EFFECTS; ANTINEOPLASTIC DRUGS; KARYOTYPE; RADIATION INJURIES; BIOLOGICAL EFFECTS; DRUGS; GAMETES; GERM CELLS; INJURIES; MEDICINE; MUTATIONS; NUCLEAR MEDICINE; RADIATION EFFECTS; RADIOLOGY; THERAPY 560151* -- Radiation Effects on Animals-- Man

Citation Formats

Genesca, A., Caballin, M.R., Miro, R., Benet, J., Bonfill, X., and Egozcue, J.. Human sperm chromosomes. Long-term effect of cancer treatment. United States: N. p., 1990. Web.
Genesca, A., Caballin, M.R., Miro, R., Benet, J., Bonfill, X., & Egozcue, J.. Human sperm chromosomes. Long-term effect of cancer treatment. United States.
Genesca, A., Caballin, M.R., Miro, R., Benet, J., Bonfill, X., and Egozcue, J.. Fri . "Human sperm chromosomes. Long-term effect of cancer treatment". United States. doi:.
@article{osti_6748895,
title = {Human sperm chromosomes. Long-term effect of cancer treatment},
author = {Genesca, A. and Caballin, M.R. and Miro, R. and Benet, J. and Bonfill, X. and Egozcue, J.},
abstractNote = {The long-term cytogenetic effect of radio- or chemotherapy or both on male germ cells was evaluated by study of the chromosomal abnormalities in spermatozoa of four men treated for cancer 5-18 years earlier. The cytogenetic analysis of 422 sperm metaphases showed no differences in the aneuploidy rate. The incidence of structural chromosome aberrations was 14.0%, however, which is much higher than in controls. Thus, the high incidence of structurally aberrant spermatozoa observed in our long-term study indicates that antitumoral treatments affect stem-cell spermatogonia and that aberrant cells can survive germinal selection and produce abnormal spermatozoa.},
doi = {},
journal = {Cancer Genetics and Cytogenetics; (USA)},
number = ,
volume = 46:2,
place = {United States},
year = {Fri Jun 01 00:00:00 EDT 1990},
month = {Fri Jun 01 00:00:00 EDT 1990}
}