Methylmercury: effect on serum enzymes and humoral antibody

Journal Article · Sun May 01 00:00:00 EDT 1977 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397709529509· OSTI ID:7211805

Koller, L D ^[1]; Exon, J H; Arbogast, B

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1. Oregon State Univ., Corvallis

Dosages of 20 and 10 ppM methylmercury were toxic to rabbits while 1 ppM did not produce clinical signs or death. Serum alkaline phosphatase levels were elevated in all rabbits exposed to methylmercury. Methylmercury-exposed rabbits challenged to A/PR8 influenza virus had hemagglutination inhibition titers as much as four times lower than those of controls. Histopathologic lesions were found in the cerebellum of rabbits that died. The most significant features of this study were that methylmercury chloride suppressed the humoral immune system and resulted in increased serum alkaline phosphatase levels, which may aid in diagnosis when methylmercury poisoning is suspected.

• OSTI ID: 7211805
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 2:5; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550500 -- Metabolism
550900 -- Pathology
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ALKALINE PHOSPHATASE
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD SERUM
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
ENZYMES
ESTERASES
HALIDES
HALOGEN COMPOUNDS
HEMAGGLUTININS
HISTOLOGY
HYDROLASES
IMMUNITY
INFLUENZA VIRUSES
INHIBITION
MAMMALS
METHYLMERCURY
MICROORGANISMS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
PARASITES
PATHOLOGY
PHOSPHATASES
RABBITS
TOXICITY
VERTEBRATES
VIRUSES