Zinc metabolism and homeostasis in rats fed a wide range of high dietary zinc levels

Journal Article · Tue Jun 01 00:00:00 EDT 1976 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-152-39358· OSTI ID:7210928

Ansari, M S; Miller, W J; Neathery, M W; Lassiter, J W; Gentry, R P; Kincaid, R L

Zinc metabolism and homeostasis were studied in young growing rats fed a 38 ppM zinc diet with added zinc levels ranging from 0 to 8400 ppM for 21 days. High dietary zinc did not cause toxicity symptoms. Stable zinc in feces increased linearly with dietary zinc intake but fecal /sup 65/Zn, from a single oral dose, did not increase above the 1200 ppM dietary level. Stable zinc in liver, kidney, and tibia increased two to three times with 2400 ppM added zinc, but was not further elevated until 8400 ppM was fed. Stable zinc in muscle and heart was not affected appreciably by dietary zinc level. In all tissues, /sup 65/Zn retention was drastically reduced with 1200 ppM added dietary zinc. Additional dietary zinc reduced /sup 65/Zn in muscle and heart but had little effect on liver and kidney /sup 65/Zn. The data indicate that rats have fairly effective homeostatic control mechanisms for tissue zinc below about 7200 ppM dietary zinc. Whereas, with dietary zinc up to about 1200 ppM, decreasing absorption is the main route of homeostatic control, above this level, more rapid zinc turnover rates and increasing endogenous zinc excretion appear to have major importance.

• Research Organization: Univ. of Georgia, Athens
• OSTI ID: 7210928
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 152:2; ISSN PSEBA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DIET
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
HEART
HOMEOSTASIS
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPES
KIDNEYS
LIVER
MAMMALS
METABOLISM
METALS
MUSCLES
NUCLEI
ORGANS
RADIOISOTOPES
RATS
RODENTS
SKELETON
TIBIA
TOXICITY
UPTAKE
VERTEBRATES
ZINC
ZINC 65
ZINC ISOTOPES