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Zinc metabolism in normal and zinc-deficient rat brain

Journal Article · · Exp. Neurol.; (United States)

Zinc uptake and turnover was measured in nine brain regions, choroid plexus, arachnoid, and cerebrospinal fluid during a 28-day period following a single dose of /sup 65/Zn in rats fed Zn-adequate diets. Zinc entry into brain was slow with maximal /sup 65/Zn uptake occurring between 5 and 14 days in contrast to its rapid metabolism in plasma and nonneural tissues. The brain stem, at the level of the caudal IV ventricle, had the highest rate of initial /sup 65/Zn uptake of any brain region. To determine if specific brain regions were particularly sensitive to changes in Zn status, /sup 65/Zn metabolism was measured in Zn-deficient rats and compared with ad libitum- and pair-fed controls. Zinc deficiency was associated with increased /sup 65/Zn retention by all brain regions; however, the effect was greatest in optic nerve and choroid plexus. The results of this study suggest that a formidable barrier to Zn entry into brain exists but is under homeostatic control, increasing net Zn uptake during dietary deficiency. Moreover, the choroid plexus may participate in cerebral Zn homeostasis, possibly by transporting Zn out of the cerebrospinal fluid compartment.

Research Organization:
Veterans Administration, Lexington, KY
OSTI ID:
6178380
Journal Information:
Exp. Neurol.; (United States), Journal Name: Exp. Neurol.; (United States) Vol. 85:1; ISSN EXNEA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBROSPINAL FLUID
DAYS LIVING RADIOISOTOPES
DIET
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HOMEOSTASIS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MATERIALS
METABOLISM
NERVOUS SYSTEM
NUCLEI
NUTRITIONAL DEFICIENCY
ORGANS
RADIOISOTOPES
RATS
RODENTS
UPTAKE
VERTEBRATES
ZINC 65
ZINC COMPOUNDS
ZINC ISOTOPES