Effects of radiations on DNA and repair of the damage. Progress report, May 1, 1974--June 30, 1977. [Gamma and UV radiation, Escherichia coli, lambda phage]
Repair of DNA double-strand breaks produced by gamma rays takes place in E. coli. Such repair requires recA function and the presence of another DNA molecule of the same base sequence, so it may involve a recombination-like event. Ultraviolet light acting on DNA containing bromouracil produces doublestrand breaks by single photochemical events, and a simple model can explain this, as well as other results. Bromouracil mutagenesis of either E. coli or lambda phage does not involve the recA or red functions. Bromouracil mutagenesis is greatly increased in E. coli mutants such as uvrE, mutL, mutR and mutS, which are defective in mismatch repair. This, and other results, suggest that bromouracil mutagenesis occurs when cell enzymes fail to remove mismatched bases. Ultraviolet mutagenesis of lambda phage may be a useful model for the study of mutagenesis in cells, because the effects of lesions in the gene mutated (i.e. in the phage) and changes in enzyme systems (by treating the host cells) can be examined separately. Quantitative data support this approach.
- Research Organization:
- Yale Univ., New Haven, CT (USA)
- OSTI ID:
- 7210876
- Report Number(s):
- COO-3571-18
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of radiations on DNA and repair of the damage. Progress report, May 1, 1976--March 31, 1977. [Escherichia coli, gamma radiation, UV radiation]
Mechanisms of mutagenesis for lambda phage
Uv-induced mutations and repair in the phage lambda system of E. coli
Technical Report
·
Fri Dec 31 23:00:00 EST 1976
·
OSTI ID:7211823
Mechanisms of mutagenesis for lambda phage
Journal Article
·
Fri Dec 31 23:00:00 EST 1982
· UCLA Symp. Mol. Cell. Biol., New Ser.; (United States)
·
OSTI ID:6539528
Uv-induced mutations and repair in the phage lambda system of E. coli
Journal Article
·
Sun Dec 31 23:00:00 EST 1972
· Stud. Biophys., v. 36-37, pp. 97-104
·
OSTI ID:4437785
Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BACTERIA
BACTERIOPHAGES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BROMOURACILS
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
MICROORGANISMS
MUTAGENESIS
NUCLEIC ACIDS
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
STRAND BREAKS
ULTRAVIOLET RADIATION
URACILS
VIRUSES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BACTERIA
BACTERIOPHAGES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BROMOURACILS
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
MICROORGANISMS
MUTAGENESIS
NUCLEIC ACIDS
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
STRAND BREAKS
ULTRAVIOLET RADIATION
URACILS
VIRUSES