Transaxial tomographic imaging of canine myocardium with /sup 11/C-palmitic acid

Journal Article · Fri Dec 31 23:00:00 EST 1976 · J. Nucl. Med.; (United States)

OSTI ID:7208205

Hoffman, E J; Phelps, M E; Weiss, E S; Welch, M J; Coleman, R E; Sobel, B E; Ter-Pogossian, M M

Radiopharmaceuticals incorporated directly into the metabolic pathways in myocardium provide a useful means for evaluating such processes. Palmitic acid, a major physiologic substrate of myocardium, has a well-understood role in myocardial metabolism. Accordingly, /sup 11/C-palmitic acid was the substrate chosen for use in conjunction with positron emission transaxial tomography to obtain images of canine myocardium. This procedure provides high-contrast images of transverse sections of the myocardium, with good target-to-nontarget ratios (in the image), over a period of 5 to 85 minutes. Clearance half-times for blood and myocardial tissue were found to be 4.8 and 330 min, respectively. In normal myocardium, images obtained with /sup 11/C-palmitic acid were compared with those obtained with /sup 13/NH/sub 3/ and /sup 11/CO-hemoglobin. In vivo images of hearts with myocardial infarcts showed a clear delineation of infarcts and normal tissue.

• Research Organization: Washington Univ. School of Medicine, St. Louis
• OSTI ID: 7208205
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 18:1; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMMONIA
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL MATERIALS
BIOMEDICAL RADIOGRAPHY
BLOOD
BLOOD CIRCULATION
BODY
BODY FLUIDS
CARBON 11
CARBON COMPOUNDS
CARBON ISOTOPES
CARBON MONOXIDE
CARBON OXIDES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEART
HEXADECANOIC ACID
HYDRIDES
HYDROGEN COMPOUNDS
IMAGE SCANNERS
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MEDICINE
METABOLISM
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NITROGEN 13
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NITROGEN ISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
TOMOGRAPHY
TRACER TECHNIQUES
VERTEBRATES