Regional assessment of myocardial metabolic integrity in vivo by positron-emission tomography with /sup 11/C-labeled palmitate

Journal Article · Thu Jan 31 23:00:00 EST 1980 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.61.2.242· OSTI ID:5342920

Ter-Pogossian, M M; Klein, M S; Markham, J; Roberts, R; Sobel, B E

To determine whether positron emission tomography (PET) after the combined administration of /sup 11/C-palmitate intravenously to image myocardium and /sup 11/CO by inhalation to image the cardiac blood pool with /sup 11/CO-hemoglobin provides quantitative delineation of the locus and extent of myocardial infarction, 28 patients with suspected myocardial infarction were studied. Twenty-one patients had electrocardiographically documented transmural infarction and in seven, the diagnosis of infarction was ultimately excluded based on enzymatic and electrocardiographic criteria. To assess reproducibility, four patients were studied on two occasions 1 month apart. Inferior and apical infarcts were readily localized with sagittal and coronal as opposed to transaxial reconstructions. Complete electrocardiographic and tomographic concordance was observed for the locus of all transmural infarcts. Reproducibility of tomographic estimates was within 10%. Tomographic estimation of the extent of infarction with /sup 11/C-palmitate in a subset of patients in whom right ventricular contributions to overall enzyme release could be excluded was facilitated by delineation of the endocardial border with the /sup 11/CO-hemoglobin cardiac blood pool image in the same plane. The correlaion between enzymatic (serial plasma MB-CK method) and tomographic estimates of infarct size was close (r = 0.92). Thus, as has been shown in experimental animals, PET with /sup 11/C-palmitate permits quantification and localization of myocardial infarcts in patients.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO
• OSTI ID: 5342920
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 61:2; ISSN CIRCA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD FLOW
BODY
CARBON 11
CARBON COMPOUNDS
CARBON ISOTOPES
CARBON MONOXIDE
CARBON OXIDES
CARBOXYHEMOGLOBIN
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
CORRELATIONS
DATA
DATA FORMS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGRAMS
DISEASES
DRUGS
ECAT SCANNING
ELECTROCARDIOGRAMS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HEART
HEXADECANOIC ACID
INFORMATION
INHALATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEASURING METHODS
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
PHOTON EMISSION SCANNING
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOPHARMACEUTICALS
TOMOGRAPHY