Effects of nitrogen oxides and their neutralization products with ammonia on the lung phospholipids of guinea pigs

Journal Article · Fri Dec 31 23:00:00 EST 1976 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(77)90070-6· OSTI ID:7208122

Trzeciak, H I; Kosmider, S; Kryk, K; Kryk, A

Male guinea pigs were chronically exposed to a gaseous mixture of nitrogen dioxide at a concentration of 0.506 ppM and nitrogen oxide at a concentration of 0.05 ppM or to the products of their neutralization by ammonia 8 hours daily for 122 days. No changes in the total lipids of lungs of the exposed animals were found as compared with the control. In the lungs of guinea pigs exposed to nitrogen oxides a statistically significant decrease of the content of phosphatidylethanolamine, sphingomyelin, phosphatidylserine, phosphatidic acid, phosphatidylglycerol 3-phosphate, and an increase of lysophosphatidylethanolamine was found. The neutralization of nitrogen oxides by ammonia has only slightly influenced the changes in concentration of individual phospholipids compared to phospholipids in whole lungs of guinea pigs exposed to nitrogen oxides.

• Research Organization: Silesian School of Medicine, Katowice-Ligota, Poland
• OSTI ID: 7208122
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 14:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMMONIA
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
CHEMICAL REACTIONS
CHEMISTRY
ESTERS
GUINEA PIGS
HYDRIDES
HYDROGEN COMPOUNDS
LIPIDS
LUNGS
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN HYDRIDES
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHOSPHOLIPIDS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES