Interaction of glutathione and ascorbic acid in guinea pig lungs exposed to nitrogen dioxide
Journal Article
·
· Res. Commun. Chem. Pathol. Pharmacol.; (United States)
OSTI ID:5172033
The interaction of two important water-soluble antioxidants, glutathione and ascorbic acid, was studied. The perfused guinea pig lung was found to contain about twice as much reduced glutathione as ascorbic acid. Nitrogen dioxide exposure decreased the levels of the two antioxidants both in vitro and in vivo. Ascorbic acid concentration was lowered to a greater extent than glutathione. The pulmonary ascorbic acid level was identical in both control and glutathione-deficient guinea pigs exposed to nitrogen dioxide, suggesting that there was little interaction between the two antioxidants in the lungs during oxidant stress.
- Research Organization:
- Univ. of Rochester, NY
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 5172033
- Journal Information:
- Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 31:1; ISSN RCOCB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIOXIDANTS
ASCORBIC ACID
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
DRUGS
GLUTATHIONE
GUINEA PIGS
LUNGS
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RODENTS
SYNERGISM
VERTEBRATES
VITAMINS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIOXIDANTS
ASCORBIC ACID
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
DRUGS
GLUTATHIONE
GUINEA PIGS
LUNGS
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RODENTS
SYNERGISM
VERTEBRATES
VITAMINS