Effect of chronic exposure to nitrogen dioxide on collagen content in lung and skin of guinea pigs

Journal Article · Wed Jun 01 04:00:00 EDT 1977 · Environ. Res.; (United States)

OSTI ID:5370742

Drozdz, M; Kucharz, E; Szyja, J

The influence of nitrogen dioxide on the connective tissue of guinea pigs was studied after 180 days (8 hours per day) of exposure at a concentration of 2 mg/m/sup 3/. The long-term exposure induced a decrease of total collagen content in lung tissue, and an increase in skin as well as an increase of collagen catabolite levels in blood serum and urine. The increase of soluble fractions of collagen and the decrease of insoluble ones was found in skin of the exposed animals. Morphological studies showed nitrogen dioxide-induced emphysema and damage in bronchioli of the lungs and some degenerative skin changes. The results obtained suggest the inhibition of collagen maturation and/or activation of its catabolism as the main mechanism of nitrogen dioxide-induced connective tissue damage.

• Research Organization: Silesian Medical School, Sosnowiec, Poland
• OSTI ID: 5370742
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 13:3; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

550800 -- Morphology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
BRONCHI
CHALCOGENIDES
COLLAGEN
DISEASES
GUINEA PIGS
LUNGS
MAMMALS
MORPHOLOGY
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PROTEINS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SCLEROPROTEINS
SKIN
TISSUES
URINE
VERTEBRATES
WASTES