Monitoring human exposure to lead: An assessment of current laboratory performance for the determination of blood lead

Journal Article · Wed Apr 01 04:00:00 EST 1992 · Environmental Research; (United States)

DOI:https://doi.org/10.1016/S0013-9351(05)80075-1· OSTI ID:7206337

Parsons, P J ^[1]

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1. New York State Dept. of Health, Albany (United States) State Univ. of New York, Albany (United States)

The performance of a small group of experienced reference laboratories performing the determination of lead in blood is assessed by means of repeated analyses of lyophilized animal blood. Both interlaboratory precision and intralaboratory precision are reported for the reference laboratory group. Results indicate that at the new blood lead action level of 10 {mu}g/100 ml, this group can achieve results that are accurate to within {plus minus} 2 {mu}g/100 ml. The capability of routine clinical laboratories participating in the New York State Department of Health's Proficiency Testing Program for Blood Lead from 1979 to 1991 is also examined. These data indicate a steady improvement in laboratory using anodic stripping voltammetry tend to underestimate the concentration of lead in blood at levels > 40 {mu}g/100 ml. The accuracy and precision of electrothermal atomization and Delves-cup atomic absorption spectrometry for the determination of blood lead in one laboratory are compared and discussed.

• OSTI ID: 7206337
• Journal Information: Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 57:2; ISSN ENVRA; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTRA
ACCURACY
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
DISTRIBUTION
ELEMENTS
INTERLABORATORY COMPARISONS
LEAD
MAMMALS
MAN
MATERIALS
MEASURING METHODS
METABOLISM
METALS
PRIMATES
SPECTRA
TISSUE DISTRIBUTION
VERTEBRATES