New developments in microscale separations and mass spectrometry for biomonitoring: Capillary electrophoresis and electrospray ionization mass spectrometry

Journal Article · Fri Jan 01 04:00:00 EST 1993 · Journal of Toxicology and Environmental Health; (United States)

DOI:https://doi.org/10.1080/15287399309531783· OSTI ID:7201155

Smith, R D; Wahl, J H; Light-Wahl, K J; Winger, B E ^[1]

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1. Pacific Northwest Lab., Richland, WA (United States)

In this article, we briefly highlight the use of capillary electrophoresis for sampling, manipulating, and separating extremely small sample sizes. The extraordinary sensitivity that can be obtained by combined capillary electrophoresis-mass spectrometry is then demonstrated using recent results. We briefly describe the ability to detect noncovalently associated complexes (e.g., double-stranded DNA) by electrospray ionization-mass spectrometry, and conclude with recent results that show the potential for using high-resolution Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry for characterization of biomolecules. 15 refs., 6 figs.

• DOE Contract Number: AC06-76RL01830
• OSTI ID: 7201155
• Journal Information: Journal of Toxicology and Environmental Health; (United States), Journal Name: Journal of Toxicology and Environmental Health; (United States) Vol. 40:2-3; ISSN 0098-4108; ISSN JTEHD6
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
BIOCHEMISTRY
CHEMISTRY
CYCLOTRON RESONANCE
ELECTROPHORESIS
FEASIBILITY STUDIES
ION CYCLOTRON-RESONANCE
MASS SPECTROSCOPY
MOLECULAR BIOLOGY
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SENSITIVITY
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