Protein tyrosine phosphatase containing SH2 domains: Characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13

Journal Article · Sat Feb 01 04:00:00 EST 1992 · Molecular and Cellular Biology; (United States)

DOI:https://doi.org/10.1128/MCB.12.2.836· OSTI ID:7200962

Yi, T; Cleveland, J L; Ihle, J N ^[1]

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1. St. Jude Children's Research Hospital, Memphis, TN (United States)

Protein tyrosine phosphorylation has been implicated in the growth and functional responses of hematopoietic cells. Recently, approaches have been developed to characterize the protein tyrosine phosphatases that may contribute to regulation of protein tyrosine phosphorylation. One novel protein tyrosine phosphatase was expressed predominantly in hematopoietic cells. Hematopoietic cell phosphatase encodes a 68-kDa protein that contains a single phosphatase conserved domain. Unlike other known protein tyrosine phosphatases, hematopoietic cell phosphatase contains two src homology 2 domains. We also cloned the human homolog, which has 95% amino acid sequence identity. Both the murine and human gene products have tyrosine-specific phosphatase activity, and both are expressed predominantly in hematopoietic cells. Importantly, the human gene maps to chromosome 12 region p12-p13. This region is associated with rearrangements in approximately 10% of cases of acute lymphocyte leukemia in children.

• OSTI ID: 7200962
• Journal Information: Molecular and Cellular Biology; (United States), Journal Name: Molecular and Cellular Biology; (United States) Vol. 12:2; ISSN 0270-7306; ISSN MCEBD4
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
CARBOXYLIC ACIDS
CARCINOGENESIS
CHEMICAL REACTIONS
CHROMOSOMES
ENZYMES
ESTERASES
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 12
HUMAN CHROMOSOMES
HYDROLASES
HYDROXY ACIDS
LEUKEMOGENESIS
MAPPING
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
PHOSPHATASES
PHOSPHORYLATION
PROTEINS
TYROSINE