Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activator tax
Journal Article
·
· Journal of Virology; (USA)
OSTI ID:7194725
- Rockefeller Univ., New York, NY (USA)
The human T-cell leukemia virus type I (HTLV-I) trans-activator (tax)-inducible enhancer was localized to three copies of 21-base-pair repeats within the long terminal repeat. Interestingly, the TGACG motif found in the center of the 21-base-pair tax-responsive element (TRE) is also present in the cyclic AMP (cAMP)-responsive elements (CREs) and activating transcription factor (ATF)-binding sites. In this study, the authors demonstrate that the three TRE-binding proteins, TREB-1, TREB-2, and TREB-3, also bind to various CREs and ATF-binding sites and that the TREs can confer upon a heterologous promoter responsiveness to various inducing agents, including tax, cAMP, and E1a. Furthermore, the transcriptional activation of the HTLV-I promoter by tax can be inhibited by several protein kinase inhibitors, including sangivamycin. The results indicate that the TREs, CREs, and ATF-binding sites are similar cis-acting elements and further suggest (i) that the transcriptional activation of the HTLV-I promoter by tax involves the action of a protein kinase an (ii) that induction by tax, cAMP, and E1a might be mediated by distinct factors or kinases.
- OSTI ID:
- 7194725
- Journal Information:
- Journal of Virology; (USA), Journal Name: Journal of Virology; (USA) Vol. 63:9; ISSN 0022-538X; ISSN JOVIA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550700* -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
CROSS-LINKING
DNA
DNA SEQUENCING
ENZYMES
GENE REPRESSORS
LEUKEMIA VIRUSES
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MICROORGANISMS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
NUCLEOPROTEINS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PLASMIDS
POLYMERIZATION
PROTEINS
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
TRANSCRIPTION FACTORS
TRANSFERASES
VIRUSES
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
CROSS-LINKING
DNA
DNA SEQUENCING
ENZYMES
GENE REPRESSORS
LEUKEMIA VIRUSES
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MICROORGANISMS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
NUCLEOPROTEINS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PLASMIDS
POLYMERIZATION
PROTEINS
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
TRANSCRIPTION FACTORS
TRANSFERASES
VIRUSES