Composition of proteoglycans in the aortas of copper-deficient rats

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Proceedings of the Society for Experimental Biology and Medicine; (USA)

DOI:https://doi.org/10.3181/00379727-190-42835· OSTI ID:7194182

Radhakrishnamurthy, B; Ruiz, H; Dalferes, Jr, E R; Klevay, L M ^[1]; Berenson, G ^[2]

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1. Louisiana State Univ. Medical Center, New Orleans (USA)
2. Department of Agriculture, Grand Forks, ND (USA)

Copper deficiency adversely affects the extracellular matrix of the arterial wall, leading to cardiovascular lesions. To study the lesions resulting from copper deficiency, the composition of proteoglycans from aortas of copper-deficient rats was compared with proteoglycans of aortas from copper-supplemented rats. Copper deficiency in rats was verified by copper levels in adrenal glands (mean {plus minus} SE, 0.37 {plus minus} 0.07 vs 1.03 {plus minus} 0.17 {mu}g/g wet wt in supplemented rats). Total uronate in the aortas from copper-deficient rats was 25% greater than in aortas from copper-supplemented rats, and the proteoglycans from copper-deficient rat aortas were of greater molecular size. Among the glycosaminoglycans the concentration ({mu}g/mg tissue) of isomeric chondroitin sulfates, particularly dermatan sulfate, was greater in copper-deficient animals than in copper-supplemented animals. These observations are similar to earlier findings in experimental atherosclerosis and to a response of cardiovascular connective tissue to injury.

• OSTI ID: 7194182
• Journal Information: Proceedings of the Society for Experimental Biology and Medicine; (USA), Journal Name: Proceedings of the Society for Experimental Biology and Medicine; (USA) Vol. 190:1; ISSN PSEBA; ISSN 0037-9727
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AORTA
ARTERIES
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMICAL COMPOSITION
COPPER
DISEASES
ELEMENTS
GLUCOPROTEINS
GLYCOPROTEINS
MAMMALS
METALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RATS
RODENTS
SACCHARIDES
TRANSITION ELEMENTS
VERTEBRATES