Transforming genes in chronic myelogenous leukemia

Journal Article · Tue Mar 01 04:00:00 EST 1988 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.85.6.1952· OSTI ID:7193263

Liu, E; Hjelle, B; Bishop, J M ^[1]

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1. Univ. of California, San Francisco (USA)

Chronic myelogenous leukemia (CML) is a hematopoietic malignancy characterized by an indolent chronic phase that invariably leads to a blast crisis indistinguishable from acute leukemia. Using a sensitive assay based on gene transfer and tumorigenesis, the authors sought evidence that damage to protooncogenes might figure in the progression from the chronic to the blast phase of CML. Seven of the 12 patients with CML examined in this manner harbored transforming genes. Mutations in RAS protooncogenes were detected in the leukemic cells from 1 or 6 chronic-phase patients, and 3 of 6 blast-crisis patients. In addition, a presently unidentified transforming gene (neither RAS nor RAF) was detected in 1 patient with chronic phase and 1 with blast crisis. These data indicate that mutations in RAS genes may play diverse roles in the pathogenesis of CML.

• OSTI ID: 7193263
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 85:6; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTORADIOGRAPHY
BIOLOGY
CARCINOGENESIS
CHROMOSOMES
CLONING
CODONS
DISEASES
DNA
DNA HYBRIDIZATION
DNA-CLONING
GENE MUTATIONS
GENES
GENETICS
HEMIC DISEASES
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
LEUKEMIA
MAMMALS
MICE
MUTATIONS
NEOPLASMS
NUCLEIC ACIDS
ONCOGENES
ORGANIC COMPOUNDS
PATHOGENESIS
PATIENTS
PHILADELPHIA CHROMOSOME
RODENTS
VERTEBRATES