Cytogenetics of fibroblastic colonies in Ph/sup 1/-positive chronic myelogenous leukemia

Journal Article · Thu Jun 01 04:00:00 EDT 1978 · Blood; (United States)

OSTI ID:6782647

Greenberg, B R; Wilson, F D; Woo, L; Jenks, H M

The cytogenetic status of bone marrow stromal elements obtained from six patients with Ph/sup 1/-positive chronic myelogenous leukemia (CML), two in blast crisis, was studied in vitro utilizing the potential of marrow to form surface-adherent colonies morphologically compatible with mesenchymal elements. We demonstrated the absence of both the market chromosome and other chromosomal abnormalities in all the fibroblastic colonies studied, indicating that the progenitors of such colonies (plaque-forming units in culture, PFU-C) are not closely related to hematopoietic elements including macrophages. This supports previous reports suggesting that the stromal elements in myelofibrosis associated with CML are not derived from the primary Ph/sup 1/-positive malignant clone but represent a stromal reactive component of benign or independent malignant potential.

• Research Organization: Univ. of California, Davis
• OSTI ID: 6782647
• Journal Information: Blood; (United States), Journal Name: Blood; (United States) Vol. 51:6; ISSN BLOOA
• Country of Publication: United States
• Language: English

Related Subjects

550300* -- Cytology
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BLOOD FORMATION
BONE MARROW CELLS
CELL CULTURES
CHROMOSOMES
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DISEASES
FIBROBLASTS
HEMIC DISEASES
LEUKEMIA
MYELOID LEUKEMIA
NEOPLASMS
PATIENTS
PHILADELPHIA CHROMOSOME
SOMATIC CELLS
STEM CELLS