Evolution of karyotypes in Philadelphia (Ph/sup 1/) chromosome-negative chronic myelogenous leukemia
Ten of 55 patients with chronic myelogenous leukemia (CML) diagnosed between 1972 and 1977 were found to lack the Philadelphia (Ph/sup 1/) chromosome. Serial clinical, morphologic, and cytogenetic studies of patients with Ph/sup 1/-negative CML showed that 30% of them had chromosomal abnormalities. Two had an extra chromosome No. 8 at the time of blast crisis, with a morphological picture of myeloblasts in the bone marrow. A third patient had a 6:14 translocation initially. Abnormalities of chromosome No. 14 are frequently seen in lymphoproliferative disorders, and the bone marrow and peripheral blood contained a significant population of lymphoblasts as well as myeloblasts. The median survival for the 10 patients was 19 months. The exact nature of Ph/sup 1/-negative CML is not yet clear; the disease appears to be a distinct entity among the myeloproliferative disorders.
- Research Organization:
- Univ. of Chicago, IL
- OSTI ID:
- 5265147
- Journal Information:
- Cancer; (United States), Journal Name: Cancer; (United States) Vol. 43:2; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Chronic myelogenous leukemia (CML) with variant Philadelphia chromosome
Cytogenetics of fibroblastic colonies in Ph/sup 1/-positive chronic myelogenous leukemia
Related Subjects
550600* -- Medicine
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BONE MARROW
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DIAGNOSTIC USES
DISEASES
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
KARYOTYPE
LEUKEMIA
MATERIALS
MUTATIONS
MYELOID LEUKEMIA
NEOPLASMS
ORGANS
PATIENTS
SURVIVAL TIME
TISSUES
USES