Bone blood flow after spinal paralysis in the rat

Journal Article · Tue May 01 00:00:00 EDT 1990 · Journal of Orthopaedic Research (New York); (USA)

DOI:https://doi.org/10.1002/jor.1100080311· OSTI ID:7192155

Takahashi, H; Yamamuro, T; Okumura, H; Kasai, R; Tada, K ^[1]

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1. Kyoto Univ. (Japan)

The goal of this study was to investigate the acute and chronic effects of paralysis induced by spinal cord section or sciatic neurotomy on bone blood flow in the rat. Regional bone blood flow was measured in the early stage with the hydrogen washout technique and the change of whole bone blood flow was measured in the early and the late stages with the radioactive microsphere technique. Four to 6 h after cordotomy at the level of the 13th thoracic vertebra, the regional bone blood flow in the denervated tibia increased significantly (p less than 0.01). After hemicordotomy with rhizotomy at the same level, the regional bone blood flow in the denervated tibia increased significantly (p less than 0.05) 6 h postoperatively. The whole bone blood flow in the denervated tibia had also increased significantly (p less than 0.05) at 6 h and at 4 and 12 weeks postoperatively. After sciatic neurotomy, the regional and the whole bone blood flow in the paralytic tibia did not change significantly. The present study demonstrated that monoplegic paralysis caused an increase in bone blood flow in the denervated hind limb from a very early stage. It was suggested that the spinal nervous system contributed to the control of bone blood flow.

• OSTI ID: 7192155
• Journal Information: Journal of Orthopaedic Research (New York); (USA), Vol. 8:3; ISSN 0736-0266
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
NERVOUS SYSTEM DISEASES
PATHOGENESIS
SKELETON
BLOOD FLOW
MICROSPHERES
RATS
SPINAL CORD
STRONTIUM ISOTOPES
TRACER TECHNIQUES
ALKALINE EARTH ISOTOPES
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NERVOUS SYSTEM
ORGANS
RODENTS
VERTEBRATES
550901* - Pathology- Tracer Techniques