Urine aldosterone radioimmunoassay: validation of a method without chromatography. [/sup 3/H]
Journal Article
·
· J. Clin. Endocrinol. Metab.; (United States)
A simplified radioimmunoassay of urinary aldosterone is reported. Acid-hydrolyzed urine was extracted with dichloromethane and the extract assayed without further purification. Urinary aldosterone values in patients with Cushing's syndrome, low and normal-renin essential hypertension, congenital adrenal hyperplasia, and primary aldosteronism determined by this method agreed closely (r = 0.95, P less than 0.01) with values obtained using a standardized chromatographic method. This simplified assay represents a significant advance in our capabilities for evaluating patients for abnormalities in aldosterone physiology.
- Research Organization:
- Mayo Clinic, Rochester, MN
- OSTI ID:
- 7190315
- Journal Information:
- J. Clin. Endocrinol. Metab.; (United States), Journal Name: J. Clin. Endocrinol. Metab.; (United States) Vol. 42:5; ISSN JCEMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ALDEHYDES
ALDOSTERONE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CORTICOSTEROIDS
HORMONES
HYDROXY COMPOUNDS
IMMUNE SERUMS
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
MINERALOCORTICOIDS
ORGANIC COMPOUNDS
PATIENTS
PREGNANES
RADIOASSAY
RADIOIMMUNOASSAY
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
URINE
WASTES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ALDEHYDES
ALDOSTERONE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CORTICOSTEROIDS
HORMONES
HYDROXY COMPOUNDS
IMMUNE SERUMS
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
MINERALOCORTICOIDS
ORGANIC COMPOUNDS
PATIENTS
PREGNANES
RADIOASSAY
RADIOIMMUNOASSAY
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
URINE
WASTES