Chemical exposures and central nervous system cancers: a case-control study among workers at two nuclear facilities

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700130305· OSTI ID:7189503

Carpenter, A V; Flanders, W D; Frome, E L; Tankersley, W G; Fry, S A

In a nested case-control study of workers employed between 1943 and 1977 at two nuclear facilities, we evaluated the possible association of primary CNS cancers with occupational exposure to chemicals. Seventy-two white male and 17 white female workers who, according to the information on death certificates, died of primary CNS cancers were identified as cases. For each case, four controls were matched on race, sex, facility at which initially employed (cohort), year of birth, and year of hire. Each job title/department combination was subjectively evaluated for potential exposure to each of 26 chemicals or chemical groups. Statistically significant associations were not found between CNS cancer deaths and any of the 26 chemicals. An increased risk of CNS cancer occurrence was observed among subjects employed for more than 20 yr (OR = 7.0, 95% CI = 1.2,41.1, cases = 9).

• Research Organization: Oak Ridge Associated Universities, TN (USA)
• OSTI ID: 7189503
• Journal Information: Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 13:3; ISSN AJIMD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENESIS
CENTRAL NERVOUS SYSTEM
DISEASES
EPIDEMIOLOGY
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NEOPLASMS
NERVOUS SYSTEM
NUCLEAR FACILITIES
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PATHOGENESIS
PERSONNEL
RADIOACTIVE MATERIALS
RADIOINDUCTION