Chemical exposures and central nervous system cancers: a case-control study among workers at two nuclear facilities
In a nested case-control study of workers employed between 1943 and 1977 at two nuclear facilities, we evaluated the possible association of primary CNS cancers with occupational exposure to chemicals. Seventy-two white male and 17 white female workers who, according to the information on death certificates, died of primary CNS cancers were identified as cases. For each case, four controls were matched on race, sex, facility at which initially employed (cohort), year of birth, and year of hire. Each job title/department combination was subjectively evaluated for potential exposure to each of 26 chemicals or chemical groups. Statistically significant associations were not found between CNS cancer deaths and any of the 26 chemicals. An increased risk of CNS cancer occurrence was observed among subjects employed for more than 20 yr (OR = 7.0, 95% CI = 1.2,41.1, cases = 9).
- Research Organization:
- Oak Ridge Associated Universities, TN (USA)
- OSTI ID:
- 6968704
- Journal Information:
- Am. J. Ind. Med.; (United States), Vol. 13:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CENTRAL NERVOUS SYSTEM
NEOPLASMS
EPIDEMIOLOGY
RADIOINDUCTION
RADIOACTIVE MATERIALS
CARCINOGENESIS
NUCLEAR FACILITIES
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PERSONNEL
DISEASES
MATERIALS
NERVOUS SYSTEM
PATHOGENESIS
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man