Radiation exposure and central nervous system cancers: A case-control study among workers at two nuclear facilities

Technical Report · Sun Mar 01 04:00:00 EST 1987

DOI:https://doi.org/10.2172/6646019· OSTI ID:6646019

Carpenter, A V; Flanders, W D; Frome, E L; Crawford-Brown, D J; Fry, S A

A nested case-control study was conducted among workers employed between 1943 and 1977 at two nuclear facilities to investigate the possible association of primary malignant neoplasms of the central nervous system (CNS) with occupational exposure to ionizing radiation from external and internal sources. Eighty-nine white male and female workers, who according to the information on death certificates dies of primary CNS cancers, were identified as cases. Four matched controls were selected for each case. External radiation exposure data were available from film badge readings for individual workers, whereas radiation dose to lung from internally deposited radionuclides, mainly uranium, was estimated from area and personnel monitoring data and was used in analyses in lieu of the dose to the brain. Matched sets were included in the analyses only if information was available for the case and at least one of the corresponding controls. Thus, the analyses of external radiation included 27 cases and 90 matched controls, and 47 cases and 120 matched controls were analyzed for the effects of radiation from internally deposited uranium. No association was observed between deaths fron CNS cancers and occupational exposure to ionizing radiation from external or internal sources. However, due to the small number of monitored subjects and low doses, a weak association could not be ruled out. 43 refs., 1 fig., 15 tabs.

• Research Organization: Oak Ridge Associated Universities, Inc., TN (USA)
• DOE Contract Number: AC05-76OR00033
• OSTI ID: 6646019
• Report Number(s): ORAU-282; ON: DE87007922
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
CENTRAL NERVOUS SYSTEM
CUMULATIVE RADIATION EFFECTS
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RADIATION EFFECTS
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SEX DEPENDENCE
US AEC
US DOE
US ERDA
US ORGANIZATIONS
Y-12 PLANT