Direct enhancement by cigarette smoke of asbestos fiber penetration and asbestos-induced epithelial proliferation in rat tracheal explants

Journal Article · Wed Jun 01 04:00:00 EDT 1988 · JNCI, J. Natl. Cancer Inst.; (United States)

DOI:https://doi.org/10.1093/jnci/80.7.518· OSTI ID:7189297

Hobson, J; Gilks, B; Wright, J; Churg, A

Tracheal explants from Sprague-Dawley rats were briefly exposed to cigarette smoke or air (control) and then to amosite asbestos. Asbestos fibers in or under the tracheal epithelium were counted and extent of hyperplastic lesions was ascertained at 24 hours, 72 hours, and 1 week after exposure. Smoke-exposed cultures showed significantly greater numbers of fibers in the epithelium and greater proliferative activity compared to findings in cultures not exposed to smoke. These observations indicate that very short exposure to cigarette smoke can directly affect the response of the epithelium to asbestos fibers and that smoke exposure need not be concurrent with asbestos exposure for such event to occur. These reactions may play a role in the greater incidences of lung cancer and asbestosis seen in asbestos-exposed workers who smoke.

• Research Organization: Univ. of British Columbia, Vancouver (Canada)
• OSTI ID: 7189297
• Journal Information: JNCI, J. Natl. Cancer Inst.; (United States), Journal Name: JNCI, J. Natl. Cancer Inst.; (United States) Vol. 80:7; ISSN JJIND
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMAL TISSUES
ANIMALS
ASBESTOS
BIOLOGICAL EFFECTS
BODY
CELL DIVISION
COLLOIDS
DISPERSIONS
EPITHELIUM
MAMMALS
PERMEABILITY
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
TISSUES
TOBACCO SMOKES
TOXICITY
TRACHEA
TRANSPLANTS
VERTEBRATES