Active oxygen species mediate asbestos fiber uptake by tracheal epithelial cells

Journal Article · Mon Oct 01 00:00:00 EDT 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:6315090

Hobson, J; Wright, J L; Churg, A ^[1]

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1. Univ. of British Columbia, Vancouver (Canada)

To examine the mechanism whereby asbestos fibers penetrate tracheal epithelial cells, we exposed rat tracheal explants to amosite asbestos alone, or with varying concentrations of substances that scavenge active oxygen species (catalase and superoxide dismutase) or prevent formation of active oxygen species (deferoxamine). All three agents decreased asbestos fiber uptake in a dose-response fashion, but no agent provided complete protection against fiber penetration. We conclude that uptake of amosite asbestos fibers is mediated in part by active oxygen species (most likely OH.), but that other mechanisms of fiber uptake must also exist.

• OSTI ID: 6315090
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Vol. 4:13; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ASBESTOS
UPTAKE
CATALASE
BIOLOGICAL FUNCTIONS
DEFEROXAMINE
SUPEROXIDE DISMUTASE
DOSE-RESPONSE RELATIONSHIPS
EPITHELIUM
INHALATION
RATS
TRACHEA
AMINES
ANIMAL TISSUES
ANIMALS
BODY
CHELATING AGENTS
ENZYMES
FUNCTIONS
INTAKE
MAMMALS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PEROXIDASES
RESPIRATORY SYSTEM
RODENTS
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology