Cigarette smoke increases the penetration of asbestos fibers into airway walls
For study of the penetration of asbestos fibers into airway walls, guinea pigs were given amosite asbestos by intratracheal instillation. Half of the animals were also exposed to cigarette smoke. Animals were sacrificed at 1 week and 1 month, and numbers of fibers in airway walls were counted in histologic sections. In both smoke-exposed and nonexposed groups, numbers of fibers per square millimeter of airway wall increased from 1 week to 1 month in the respiratory bronchioles. At each time period, smoke-exposed animals had significantly higher numbers of fibers in the airway walls, compared with nonexposed animals. It is concluded that 1) continued transport of fibers into interstitial tissues may be the reason that asbestosis can progress after cessation of exposure; 2) cigarette smoke increases the penetration of fibers into airway walls. This effect may play a role in the increased incidence of disease seen in smoking, compared with nonsmoking, asbestos workers.
- Research Organization:
- Univ. of British Columbia, Vancouver
- OSTI ID:
- 5614737
- Journal Information:
- Am. J. Pathol.; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ASBESTOS
RETENTION
TOBACCO SMOKES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BRONCHI
EPITHELIUM
FIBERS
GUINEA PIGS
PERSONNEL
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
AEROSOLS
ANIMAL TISSUES
ANIMALS
BODY
COLLOIDS
DISEASES
DISPERSIONS
MAMMALS
RESIDUES
RODENTS
SMOKES
SOLS
TISSUES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550900 - Pathology