Long-term consequences of exposure to ozone. I. Lung collagen content

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(84)90254-0· OSTI ID:7188729

Last, J A; Reiser, K M; Tyler, W S; Rucker, R B

Lung collagen content of rats and monkeys (Macaca fascicularis) exposed to ozone for 1 to 13 weeks and for 1 year, respectively, was quantified by measurement of 4-hydroxyproline in hydrolysates of whole lungs. In addition, ratios of type I to type III collagen in the lungs of the same monkeys were also evaluated by cyanogen bromide peptide mapping techniques. We observed elevated levels of collagen in lungs of both species of animals exposed to ozone. We conclude that elevations in collagen synthesis rates in lungs of rats and monkeys acutely exposed to high levels of ozone are reflected by corresponding increases in lung collagen content over subchronic and chronic time frames. Preliminary results on young rats also suggest that removal of rats from atmospheres containing ozone does not cause reversal of such increases in lung collagen content. To the contrary, recovery periods of up to 6 weeks seem to exacerbate the observed increases in lung collagen content.

• Research Organization: California Primate Research Center, Davis
• OSTI ID: 7188729
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 72:1; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACID SEQUENCE
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHRONIC EXPOSURE
COLLAGEN
DOSE-RESPONSE RELATIONSHIPS
FIBROSIS
LUNGS
MACACUS
MAMMALS
MOLECULAR STRUCTURE
MONKEYS
ORGANIC COMPOUNDS
ORGANS
OZONE
PATHOLOGICAL CHANGES
PRIMATES
PROTEINS
RATS
RESPIRATORY SYSTEM
RODENTS
SCLEROPROTEINS
VERTEBRATES