Aldosterone response to angiotensin II during hypoxemia
Journal Article
·
· J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States)
OSTI ID:7188166
Exercise stimulates the renin-angiotensin-aldosterone system (RAAS). However, increases in plasma aldosterone concentrations (PAC) are suppressed when exercise is performed at high altitude or under hypoxemic conditions. As the angiotensin-II response to high-altitude exercise is normal, it is speculated that an inhibitor, discharged during hypoxemia, acted to suppress angiotensin-II-mediated aldosterone release. A study was conducted to test this hypothesis, taking into account the measurement of the aldosterone response to exogenous angiotensin II during normoxemia and hypoxemia. It was found that the dose-response curve of PAC to angiotensin II was not significantly inhibited by the considered model of hypoxemia. The hypoxemia-mediated release of an angiotensin II inhibitor does, therefore, not explain the previous observations of PAC suppression during hypoxemic exercise. 28 references.
- Research Organization:
- Medical Regional Office Center, White River Junction, VT; South Florida Univ., Tampa
- OSTI ID:
- 7188166
- Journal Information:
- J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States), Journal Name: J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States) Vol. 61; ISSN JARPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALDEHYDES
ALDOSTERONE
ANGIOTENSIN
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BLOOD
BLOOD PLASMA
BLOOD PRESSURE
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
CORTICOSTEROIDS
DRUGS
EXERCISE
GLOBIN
GLOBULINS
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MATERIALS
MINERALOCORTICOIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PREGNANES
PROTEINS
STEROID HORMONES
STEROIDS
VASOCONSTRICTORS
VASODILATION
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALDEHYDES
ALDOSTERONE
ANGIOTENSIN
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BLOOD
BLOOD PLASMA
BLOOD PRESSURE
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
CORTICOSTEROIDS
DRUGS
EXERCISE
GLOBIN
GLOBULINS
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MATERIALS
MINERALOCORTICOIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PREGNANES
PROTEINS
STEROID HORMONES
STEROIDS
VASOCONSTRICTORS
VASODILATION