Cortisol-induced inhibition of ovine renin and aldosterone responses to hypotension

Journal Article · Sun Mar 01 04:00:00 EST 1987 · Am. J. Physiol.; (United States)

OSTI ID:5432697

Wood, C E; Silbiger, J

Previous studies from this laboratory have demonstrated that in preterm fetal sheep increases in plasma cortisol (F) concentration equal in amplitude to fetal F stress responses suppress plasma renin activity (PRA). The purpose of this study was to investigate the possibility that this negative interaction exists in adult sheep. Cortisol was measured by radioimmunoassay. Five conscious ewes with chronically prepared carotid arterial loops were infused intravenously with F or vehicle for 5 h. One hour after the end of F or vehicle infusion, renin secretion was stimulated by hypotension produced by infusion of sodium nitroprusside. F infusion increased plasma F; during vehicle infusion plasma F did not change. F infusion decreased hematocrit from 29 +/- 2 to 26 +/- 1%. Basal PRA in vehicle- and F-infused groups were 0.4 +/- 0 and 0.2 +/- 0.1 ng angiotensin I-ml/sup -1/-h/sup -1/ and did not change. In vehicle-infused ewes, PRA increased from 0.4 +/- 0 to 4.6 +/- 0.4 and plasma aldosterone from 26.0 +/- 1.0 to 173.1 +/- 21.8 pg/ml, while in F-infused ewes, PRA increased from 0.2 +/- 1 to 3.3 +/- 0.4 ng angiotensin I-ml/sup -1/-h/sup -1/ and aldosterone from 25.0 +/- 0 to 48.2 +/- 23.2 pg/ml, significantly smaller responses. These results suggest that repeated stress may modulate the responses of the renin-angiotensin system in this species.

• Research Organization: Univ. of Florida College of Medicine, Gainesville
• OSTI ID: 5432697
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:3; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACTH
ADRENAL HORMONES
ALDEHYDES
ALDOSTERONE
ANGIOTENSIN
ANIMALS
BIOCHEMISTRY
CARDIOVASCULAR AGENTS
CHEMISTRY
CORTICOSTEROIDS
DOMESTIC ANIMALS
DRUGS
ENZYME ACTIVITY
ENZYMES
GLOBULINS
GLUCOCORTICOIDS
HOMEOSTASIS
HORMONES
HYDROCORTISONE
HYDROLASES
HYDROXY COMPOUNDS
HYPOTENSION
IMMUNOASSAY
IMMUNOLOGY
INHIBITION
ISOTOPE APPLICATIONS
KETONES
MAMMALS
MINERALOCORTICOIDS
NONSPECIFIC PEPTIDASES
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PEPTIDE HYDROLASES
PHYSIOLOGY
PITUITARY HORMONES
PREGNANES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RENIN
RUMINANTS
SHEEP
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
VASOCONSTRICTORS
VERTEBRATES