Calcium channel blocker prevents stress-induced activation of renin and aldosterone in conscious pig

Journal Article · Sat Jun 01 04:00:00 EDT 1991 · Cardiovascular Drugs and Therapy; (United States)

DOI:https://doi.org/10.1007/BF03029733· OSTI ID:5018065

Ceremuzynski, L K; Klos, J; Barcikowski, B; Herbaczynska-Cedro, K ^[1]

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1. Department of Cardiology, Postgraduate Medical School, Warsaw (Poland)

A considerable amount of data suggest the involvement of calcium-mediated processes in the activation of the renin-angiotensin-aldosterone (RAA) cascade. To investigate the effect of calcium-channel inhibition on the RAA system, the authors studied 21 conscious pigs. Blood renin and aldosterone levels increased by subjecting animals to 24 hours of immobilization stress. Renin and aldosterone levels were repeatedly measured by radioimmunoassay in blood samples taken periodically over 24 hours from a chronically implanted arterial cannula. Pretreatment of the animals (N = 11) with nisoldipine, 2 {times} 20 mg p.o. daily for 2 days before and on the day of immobilization, transiently attenuated the stress-induced increase of plasma renin activity and completely prevented the rise of aldosterone, as compared to nontreated controls (N = 10). The finding that nisoldipine suppresses RAA activation induced by a nonpharmacologic stimulus in the conscious intact animal may have clinical implications.

• OSTI ID: 5018065
• Journal Information: Cardiovascular Drugs and Therapy; (United States), Journal Name: Cardiovascular Drugs and Therapy; (United States) Vol. 5:3; ISSN CDTHE; ISSN 0920-3206
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALDEHYDES
ALDOSTERONE
ANGIOTENSIN
ANIMALS
BIOASSAY
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL STRESS
BIOSYNTHESIS
CARDIOVASCULAR AGENTS
CORTICOSTEROIDS
DIAGNOSTIC TECHNIQUES
DOMESTIC ANIMALS
DRUGS
ENZYME INHIBITORS
ENZYMES
GLOBULINS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
INHIBITION
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
KINETICS
MAMMALS
MEMBRANE PROTEINS
MINERALOCORTICOIDS
NONSPECIFIC PEPTIDASES
ORGANIC COMPOUNDS
PEPTIDE HYDROLASES
PORINS
PREGNANES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
REACTION KINETICS
RENIN
STEROID HORMONES
STEROIDS
SWINE
SYNTHESIS
TRACER TECHNIQUES
VASOCONSTRICTORS
VERTEBRATES