Effect of hepatectomy on the reticuloendothelial system of septic rats

Journal Article · Wed Jun 01 04:00:00 EDT 1988 · J. Trauma; (United States)

DOI:https://doi.org/10.1097/00005373-198806000-00025· OSTI ID:7185427

Vo, N M; Chi, D S

The purpose of this study was to evaluate the function of the reticuloendothelial system (RES) of sham hepatectomy and 20% and 50% partial hepatectomy (PH 20%, PH 50%), with or without cecal ligation and puncture-induced sepsis. The animals were injected with 51-Chromium sheep red blood cells (SRBC) at 72 hours. SRBC half life (T1/2) was measured as an index of RES function and the percentage distribution of SRBC in liver, lung, and spleen was calculated. T1/2 was significantly prolonged in PH 50% rats and was associated with decreased radioactive uptake by the liver. Mortality was nil in the control groups and markedly increased in the presence of sepsis. The results suggest that decreased RES function following hepatectomy is dependent upon the proportion of liver removed and that sepsis further increased the mortality of hepatectomized animals.

• Research Organization: Veterans Administration Medical Center, Johnson City, TN (USA)
• OSTI ID: 7185427
• Journal Information: J. Trauma; (United States), Journal Name: J. Trauma; (United States) Vol. 28:6; ISSN JOTRA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
FUNCTIONS
GLANDS
HEPATECTOMY
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MATERIALS
MEDICINE
NUCLEI
ORGANS
RADIOISOTOPES
RATS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SURGERY
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
VERTEBRATES