Deficiency of gamma-ray excision repair in skin fibroblasts from patients with Fanconi's anemia. [5,6-dihydroxydihydrothymine]
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
The capacity of preparations of skin fibroblasts from normal individuals and patients with Fanconi's anemia to excise gamma-ray products of the 5,6-dihydroxydihydrothymine type from exogenous DNA was investigated. The excision capacity of whole-cell homogenates of fibroblasts from two of four patients with Fanconi's anemia was substantially below normal. This repair deficiency was further pronounced in nuclear preparations from cells of the same two patients.
- Research Organization:
- Univ. of Florida, Gainesville
- OSTI ID:
- 7181876
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 73:7; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560111 -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CONNECTIVE TISSUE CELLS
DISEASES
DNA
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GAMMA RADIATION
HEMIC DISEASES
IONIZING RADIATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SKIN
SOMATIC CELLS
SYMPTOMS
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CONNECTIVE TISSUE CELLS
DISEASES
DNA
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GAMMA RADIATION
HEMIC DISEASES
IONIZING RADIATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SKIN
SOMATIC CELLS
SYMPTOMS