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Effects of ionizing radiation on cells from Fanconi's anemia patients

Journal Article · · Cancer Res.; (United States)
OSTI ID:5854702
;

The lymphocytes from some Fanconi's anemia patients appeared to be more radiosensitive than normal as measured by the number of X-ray-(or bleomycin-) induced chromosome aberrations seen following G2 treatment. Fibroblasts from the same patients, however, all showed the same degree of colony survival as normals following exposure to gamma-rays (Do, 1.13 +/- 0.072 (S.E.) Gy and 1.14 +/- 0.077 Gy for Fanconi's anemia and normal fibroblasts, respectively). The lack of increased radiosensitivity in Fanconi's fibroblasts was also observed by the same degree of inhibition of DNA synthesis as seen in normals following gamma-irradiation. The results show clearly that there is no increase in radiosensitivity common to all cell types from Fanconi's patients, although an apparent increase in chromosomal radiosensitivity may be seen in the lymphocytes from an occasional patient.

Research Organization:
Medical School, Birmingham, England
OSTI ID:
5854702
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 45:1; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMAL CELLS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLEOMYCIN
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPLICATION
DRUGS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GAMMA RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HEMIC DISEASES
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTATIONS
NUCLEIC ACID REPLICATION
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
SOMATIC CELLS
SURVIVAL TIME
SYMPTOMS
X RADIATION