Cadmium-109 metabolism in mice. IV. Diet versus maternal stores as a source of cadmium transfer to mouse fetuses and pups during gestation and lactation
- Eastern Washington Univ., Cheney, WA (United States)
- Stonehill College, North Easton, MA (United States)
- Argonne National Lab., IL (United States)
The transfer of [sup 109]Cd from dam to offspring during gestation and lactation was studied in uniparous mice. From 70 to 210 d of age and during the subsequent reproductive period, young adult female mice received drinking water containing tracer amounts of [sup 109]Cd (8 Cd). The nutrient quality of the deficient diet was patterned after that consumed by Japanese women who contracted itai-itai disease. To evaluate established maternal stores as a potential source of cadmium transfer to pups, some dams were switched to water with no [sup 109]Cd and diet with an environmental or control level of cadmium (0.25 ppm Cd) during the reproductive period. The resulting pups were analyzed for [sup 109]Cd at birth and at 7-d intervals throughout the lactation period. Pup [sup 109]Cd content at birth, representative of the amount transferred via the placenta during gestation, accounted for less than 1% of the total [sup 109]Cd transferred during the full reproductive period. During lactation, [sup 109]Cd levels in pups from dams with current [sup 109]Cd exposure approximately tripled with each 7-d interval; no significant differences occurred due to nutrient quality of the dams' diet. For 21-d-old pups, 98% of the [sup 109]Cd burden came from the diet of the dam, while only 2% came from her tissue stores, primarily the hepatic one. Such fractions represented a transfer per pup of about 0.01% of the oral [sup 109]Cd dose ingested by the dam during the reproductive period and about 0.05% of the [sup 109]Cd in her tissue stores. Overall, transfer per litter amounted to about 7% of the dietary [sup 109]Cd dose absorbed and retained by the dam during that interval and about 0.2% of the [sup 109]Cd from tissue stores. On lactation d 21, 90% of the total [sup 109]Cd in pups was sequestered in the gastrointestinal tract. Cadmium transfer was additionally examined in multiparous mice that began a repetitive breeding program at 70 d of age.
- DOE Contract Number:
- W-31-109-ENG-38
- OSTI ID:
- 7181298
- Journal Information:
- Journal of Toxicology and Environmental Health; (United States), Vol. 40:4; ISSN 0098-4108
- Country of Publication:
- United States
- Language:
- English
Similar Records
Metabolism and toxicity of cadmium and lead during pregnancy and lactation
Cadmium-109 metabolism in mice. III. Organ retention in mice ovariectomized after experiencing multiple rounds of gestation and lactation
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CADMIUM 109
METABOLISM
MICE
LACTATION
PRENATAL EXPOSURE
ANIMALS
BETA DECAY RADIOISOTOPES
CADMIUM ISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NUCLEI
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560300* - Chemicals Metabolism & Toxicology
550500 - Metabolism