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Metabolism and toxicity of cadmium and lead during pregnancy and lactation

Technical Report ·
OSTI ID:5577533

Four projects relating to the metabolism and toxicity of cadmium and lead during pregnancy and lactation are summarized. Increased GI absorption and accumulation of cadmium is increased in the tissues of the mother during pregnancy and lactation in the mouse, but very little cadmium is transferred to pups. Greater than 90% of the cadmium that is transferred to pups during lactation comes from the diet not from previous body stores. Female mice exposed to a deficient Itai-Itai household diet and 50 ppM Cd show cadmium-induced decreases in reproductive parameters. Multiparous mice exposed to 50 ppM Cd develop changes in bone mineral content possibly related to similar changes seen in Itai-Itai disease. Lead absorption by the mouse dam increases only slightly during lactation, but lead is readily transferred to pups.

Research Organization:
Argonne National Lab., IL (USA)
DOE Contract Number:
W-31109-ENG-38
OSTI ID:
5577533
Report Number(s):
CONF-8310197-2; ON: DE84003673
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ALPHA DECAY RADIOISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
CADMIUM 109
CADMIUM ISOTOPES
CLEARANCE
DATA
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
FETUSES
HEAVY NUCLEI
INFORMATION
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPES
LACTATION
LEAD 210
LEAD ISOTOPES
NUCLEI
NUMERICAL DATA
NUTRITIONAL DEFICIENCY
PREGNANCY
RADIOISOTOPES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
VITAMIN D
VITAMINS
YEARS LIVING RADIOISOTOPES