Cadmium-109 metabolism in mice. III. Organ retention in mice ovariectomized after experiencing multiple rounds of gestation and lactation
- Eastern Washington Univ., Cheney (United States)
- Argonne National Lab., IL (United States)
Organ retention of [sup 109]Cd was studied in multiparous female mice 6 wk after ovariectomy of sham-control surgery. Females previously had experienced from three to five rounds of gestation/lactation during a maximum of 5 successive, 42-d reproductive periods. Throughout the experiment, mice were provided with tracer amounts of [sup 109]Cd in drinking water as well as stable Cd appropriate for the itai-itai experience in solid diets otherwise sufficient or deficient in nutrient quality. For sufficient-diet females, organ [sup 109]Cd content and concentration values were somewhat lower in the ovariectomized group compared to the sham control group. For deficient-diet females, the opposite trend occurred. When ovariectomized groups were compared with round 5 breeder groups of the same dietary experience, in almost all instances organ [sup 109]Cd content and concentration values were lower in the ovariectomized animals. Exceptions to this trend occurred in hepatic and especially renal tissues, where [sup 109]Cd concentrations were higher in the deficient-diet, ovariectomized group. Finally, when the deficient-diet, ovariectomized group was compared with its sufficient-diet counterpart, significantly higher [sup 109]Cd content values were found for liver, kidneys, and whole body (minus GI tract) in the former group. Conversely, when the same tissue content values were compared between the sham-control groups, differences without exception proved to be nonsignificant. 10 refs., 3 tabs.
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 7061807
- Journal Information:
- Journal of Toxicology and Environmental Health; (United States), Journal Name: Journal of Toxicology and Environmental Health; (United States) Vol. 38:2; ISSN 0098-4108; ISSN JTEHD6
- Country of Publication:
- United States
- Language:
- English
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560160* -- Radionuclide Effects
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
CADMIUM 109
CADMIUM ISOTOPES
DIET
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DISTRIBUTION
DRINKING WATER
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FEMALE GENITALS
FEMALES
GASTROINTESTINAL TRACT
GLANDS
GONADS
HYDROGEN COMPOUNDS
INGESTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LACTATION
LIVER
MAMMALS
MEDICINE
METABOLISM
MICE
NUCLEI
NUTRITIONAL DEFICIENCY
ORGANS
OVARIES
OXYGEN COMPOUNDS
PREGNANCY
RADIOISOTOPES
REPRODUCTIVE DISORDERS
RETENTION
RODENTS
SURGERY
TISSUES
TOXICITY
UROGENITAL SYSTEM DISEASES
VERTEBRATES
WATER
YEARS LIVING RADIOISOTOPES