Cadmium-109 metabolism in mice. I. Organ retention in mice fed a nutritionally sufficient diet during successive rounds of gestation and lactation
- Eastern Washington, Univ., Cheney (United States)
- Argonne National Lab., IL (United States)
Organ retention of [sup 109]Cd was studied in multiparous and virgin female mice provided tracer amounts of [sup 109]Cd in drinking water and stable Cd appropriate for the itai-itai experience in an otherwise nutrient replete solid diet. Breeder females maximally experienced 6 consecutive, 42-d rounds of gestation/lactation. On a round-by-round basis, breeder organ [sup 109]Cd content and concentration values were compared with those from their time-matched virgin controls. By the end of round 5, the [sup 109]Cd contents of some organs appeared to have plateaued in consecutive breeders. Comparing breeder with control values at that point, the following increases were observed: whole body (minus gastrointestinal tract), 4.7-fold; mammary tissue, 14.1-fold; liver, 5.9-fold; and kidney, 3.8-fold. For [sup 109]Cd concentrations, analogous increases were mammary tissue, 15.3-fold; liver, 4.0-fold; and kidney, 2.4-fold. Through the six rounds, a temporal shift in fractional [sup 109]Cd distribution was noted for breeder tissues where transfer occurred from those of the mammaries, remaining carcass, and liver to the kidneys. In spite of this shift, at the end of round 6 [sup 109]Cd content in hepatic tissue still exceeded that in renal tissue; however, [sup 109]Cd concentration was 3.3-fold greater in the kidneys. For virgin female mice over the same period, a relatively smaller shift was observed from remaining carcass to kidneys. Unlike breeders, [sup 109]Cd content was identical in hepatic and renal tissues, while [sup 109]Cd concentration was 4.6-fold greater in the kidneys. With respect to renal [sup 109]Cd increases, the larger portion of these shifts had occurred by the end of round 2 for virgin mice and by the end of round 6 for breeder mice. 19 refs., 2 tabs.
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 6703440
- Journal Information:
- Journal of Toxicology and Environmental Health; (United States), Journal Name: Journal of Toxicology and Environmental Health; (United States) Vol. 38:2; ISSN 0098-4108; ISSN JTEHD6
- Country of Publication:
- United States
- Language:
- English
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560160* -- Radionuclide Effects
Kinetics
& Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
CADMIUM 109
CADMIUM ISOTOPES
DIET
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DISTRIBUTION
DRINKING WATER
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FEMALES
GASTROINTESTINAL TRACT
GLANDS
HYDROGEN COMPOUNDS
INGESTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LACTATION
LIVER
MAMMALS
METABOLISM
MICE
NUCLEI
ORGANS
OXYGEN COMPOUNDS
PREGNANCY
RADIOISOTOPES
REPRODUCTIVE DISORDERS
RETENTION
RODENTS
TISSUES
TOXICITY
UROGENITAL SYSTEM DISEASES
VERTEBRATES
WATER
YEARS LIVING RADIOISOTOPES