In vivo labeling effectiveness of tritiated thymidine of high and low specific activities in rabbits
Journal Article
·
· Radiat. Res.; (United States)
Into rabbits bearing 15-day BCG lesions, tritiated thymidine (/sup 3/HT) of specific activity of 20 or 2 Ci/mmole was injected intravenously as a single dose of 0.5 ..mu..Ci/g of body weight. The rabbits were sacrificed 30 min later. /sup 3/HT of low specific activity contained 10 times more thymidine (''hot'' plus ''cold'') per milliliter, but the same amount of hot thymidine per milliliter as /sup 3/HT of high specific activity. The /sup 3/HT grain counts on cells in the bone marrow, in the dermal BCG lesions and in the intestinal tract were not higher in the group receiving /sup 3/HT of high specific activity. In other words, when the same dose of radioactivity was administered, the labeling effectiveness of /sup 3/HT of low specific activity was equal to the effectiveness of /sup 3/HT of high specific activity.
- Research Organization:
- Johns Hopkins Univ., Baltimore
- OSTI ID:
- 7175910
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 67:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE MARROW
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
IN VIVO
INTESTINES
ISOTOPES
LABELLING
LIGHT NUCLEI
MAMMALS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RABBITS
RADIOISOTOPES
RIBOSIDES
THYMIDINE
TISSUES
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE MARROW
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
IN VIVO
INTESTINES
ISOTOPES
LABELLING
LIGHT NUCLEI
MAMMALS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RABBITS
RADIOISOTOPES
RIBOSIDES
THYMIDINE
TISSUES
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES