Chronobiological organization of reproduction of Ehrlich's ascites tumor cells

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

OSTI ID:7166099

Stepanenko, V A

The rhythms of cell proliferation and DNA synthesis were studied in a hypotetraploid strain of Ehrlich's ascites tumor (EAT) and compared with data obtained previously on the hyperdiploid strain of EAT. Eighty-five noninbred male albino mice were used. An injection of tritium-thymidine, with specific radioactivity of 4.1 Ci/mmole, was given to the mice one hour before sacrifice. The results obtained are presented; it is shown that the number of DNA-synthesizing cells in the hypotetraploid strain during the 5th and 6th days of growth of EAT was 503 and 479 /sup 0//00, respectively. Fluctuations of the radioactive index during these days were not significant. Only a significant fall in the radioactive index toward noon on the seventh day of development of the hypotetraploid strain of EAT was observed.

• Research Organization: N.I. Pirogor Second Moscow Medical Institute
• OSTI ID: 7166099
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:8; ISSN BEXBA
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ASCITES TUMOR CELLS
AUTORADIOGRAPHY
AZINES
BIOSYNTHESIS
CELL DIVISION
CELL PROLIFERATION
DAILY VARIATIONS
DNA
EHRLICH ASCITES TUMOR
EXPERIMENTAL NEOPLASMS
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MICE
MITOSIS
MITOTIC INDEX
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PLOIDY
PYRIMIDINES
RIBOSIDES
RODENTS
SYNTHESIS
THYMIDINE
TRITIUM COMPOUNDS
TUMOR CELLS
VARIATIONS
VERTEBRATES