Chronobiological characteristics of the action of thyroxine of reproduction of Ehrlich's Ascites Tumor cells

Journal Article · Wed May 01 04:00:00 EDT 1985 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

OSTI ID:7166066

Stepanenko, V A; Romanov, Y A

This paper studies the action of thyroxine on cell proliferation in a hyperdiploid strain of Ehrlich's Ascites Tumor (EAT) depending on clock time. Five albino mice were given an injection of tritium-thymidine in a dose of 0.5 u Ci/g body weight (specific radioactivity 4.1 Ci/mmole) one hour before sacrifice. On autoradiographs from each animal, during examination of 3000-5000 cells, the number of dividing and DNA-synthesizing cells was counted and mitotic index and radioactive index were calculated and expressed in promille. Parameters method and the results were subjected to statistical analysis by the Fisher-Student method. Differences were considered significant at the P less than 0.05 level.

• Research Organization: NI. Pirogov Second Moscow Medical Institute
• OSTI ID: 7166066
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 98:12; ISSN BEXBA
• Country of Publication: United States
• Language: English

Related Subjects

550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ASCITES TUMOR CELLS
AUTORADIOGRAPHY
AZINES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
CARBOXYLIC ACIDS
CELL DIVISION
CELL PROLIFERATION
DNA
GROWTH
HETEROCYCLIC COMPOUNDS
HORMONES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MICE
MITOGENS
MITOSIS
MITOTIC INDEX
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDE HORMONES
PYRIMIDINES
RADIORECEPTOR ASSAY
RIBOSIDES
RODENTS
STIMULATION
SYNTHESIS
THYMIDINE
THYROID HORMONES
THYROXINE
TIME DEPENDENCE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
VERTEBRATES