Effect of various doses of chalone-containing alcohol precipitate from Ehrlich's ascites tumor on mitotic activity and DNA synthesis in that tumor

Journal Article · Mon Jun 01 04:00:00 EDT 1987 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00840153· OSTI ID:5625349

Matsak, N Ya; Romanov, Yu A; Antokhin, A I

Experiments were carried out on noninbred male albino mice to assess the effects of varying doses of chalone-containing alcohol precipitates on mitotic activity and DNA synthesis in Ehrlich ascites tumor. Histological preparations of the tumor and small intestine were made by standard methods. Hydrolysis of the tumor in HCl was carried out before application of the nuclear photographic emulsion in order to prepare autoradiographs of the tumor. Tritium-labelled thymidine was injected as the radioactive marker.

• Research Organization: N. I. Pirogov Second Moscow Medical Institute, USSR
• OSTI ID: 5625349
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 103:1; ISSN BEXBA
• Country of Publication: United States
• Language: English

Related Subjects

550301 -- Cytology-- Tracer Techniques
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
AZINES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CELL PROLIFERATION
CHEMISTRY
CYTOCHEMISTRY
DIGESTIVE SYSTEM
DNA
DNA REPLICATION
DOSE-RESPONSE RELATIONSHIPS
EHRLICH ASCITES TUMOR
EPITHELIUM
EXPERIMENTAL NEOPLASMS
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INHIBITION
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MICE
MITOTIC INDEX
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
PYRIMIDINES
RIBOSIDES
RODENTS
SMALL INTESTINE
SYNTHESIS
THYMIDINE
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
VERTEBRATES