Effects of corn oil and benzyl acetate on number and size of azaserine-induced foci in the pancreas of LEW and F344 rats

Journal Article · Mon Sep 01 04:00:00 EDT 1986 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8668197· OSTI ID:7145143

Longnecker, D S; Roebuck, B D; Curphey, T J; Lhoste, E; Coon, C I; MacMillan, D

The response of LEW and F344 strain rats to the pancreatic carcinogen azaserine was compared using the size and number of azaserine-induced acidophilic acinar cell foci and nodules as parameters in a 4-month experiment. A second experiment compared the effect of corn oil intake by gavage and dietary routes on the growth of azaserine-induced pancreatic lesions in LEW rats. A third experiment tested the activity of benzyl acetate in regard to its ability to induce acinar cell foci or to promote the growth of such foci in azaserine-treated rats. The results showed that equivalent doses of azaserine induce two to seven times more foci in LEW than in F344 rats, and that LEW rats have a higher incidence of spontaneous foci than F344 rats. Azaserine-treated LEW rats that were given 5 mL corn oil/kg body weight 5 days per week by gavage developed more acinar cell foci than rats fed a basal diet (chow). Addition of an equivalent amount of corn oil to chow had a similar effect of enhancing the development of foci. Rats of neither strain developed acinar cell foci when benzyl acetate was given by gavage or in the diet nor was there evidence that benzyl acetate has a significant effect on the development of foci in azaserine-treated rats. These studies also demonstrate that the azaserine/rat model of pancreatic carcinogenesis which was developed in LEW rats can be adapted for use with F344 rats.

• Research Organization: Dartmouth Medical School, Hanover, NH
• OSTI ID: 7145143
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 68; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
AMINO ACIDS
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CARCINOGENESIS
CORN OIL
DIET
DIGESTIVE SYSTEM
ENDOCRINE GLANDS
ESTERS
GLANDS
HISTOLOGY
HYDROXY ACIDS
INGESTION
INTAKE
LIPIDS
MAMMALS
OILS
ORAL ADMINISTRATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PANCREAS
PATHOGENESIS
RATS
RODENTS
SERINE
TRIGLYCERIDES
VEGETABLE OILS
VERTEBRATES