Diversity and structure of human T-cell receptor. cap alpha. -chain variable region genes
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
The nucleotide sequences of 27 T-cell receptor ..cap alpha..-chain variable region (V/sub ..cap alpha../)-containing cDNA clones isolated from a cDNA library derived from human peripheral blood lymphocytes were determined. Eighteen different V/sub ..cap alpha../ and 26 different joining (J/sub ..cap alpha../) gene segments are utilized in these clones. The V/sub ..cap alpha../ gene segments belong to 12 different subfamilies, each containing from one to seven members. Comparisons with the 16 different V/sub ..cap alpha../ and 21 different J..cap alpha.. sequences previously reported suggest that the germ-line repertoires for these gene segments are greater than previously estimated. Flexibility in the sites of gene segment joining and possibly N-region diversification also contribute to human ..cap alpha..-chain diversity. Comparisons of human V/sub ..cap alpha../ regions indicate a high degree of variability spread uniformly across the entire V/sub ..cap alpha../ region without obvious hypervariable regions. However, amino acids important for the maintenance of V gene structure are conserved.
- Research Organization:
- California Institute of Technology, Pasadena (USA)
- OSTI ID:
- 7143444
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:19; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGGLUTININS
AMINO ACID SEQUENCE
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DNA SEQUENCING
ELECTROPHORESIS
GENES
HELA CELLS
HEMAGGLUTININS
IMMUNOLOGY
ISOTOPES
LEUKOCYTES
LIGHT NUCLEI
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MEMBRANE PROTEINS
MITOGENS
MOLECULAR STRUCTURE
MUCOPROTEINS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PHYTOHEMAGGLUTININ
POLYSACCHARIDES
PRIMATES
PROTEINS
RADIOISOTOPES
RECEPTORS
SACCHARIDES
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AGGLUTININS
AMINO ACID SEQUENCE
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DNA SEQUENCING
ELECTROPHORESIS
GENES
HELA CELLS
HEMAGGLUTININS
IMMUNOLOGY
ISOTOPES
LEUKOCYTES
LIGHT NUCLEI
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MEMBRANE PROTEINS
MITOGENS
MOLECULAR STRUCTURE
MUCOPROTEINS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PHYTOHEMAGGLUTININ
POLYSACCHARIDES
PRIMATES
PROTEINS
RADIOISOTOPES
RECEPTORS
SACCHARIDES
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES