Age-related changes in regional cerebral blood flow and brain volume in healthy subjects

Journal Article · Fri Apr 01 04:00:00 EST 1988 · J. Am. Geriatr. Soc.; (United States)

DOI:https://doi.org/10.1111/j.1532-5415.1988.tb02353.x· OSTI ID:7142797

Takeda, S; Matsuzawa, T; Matsui, H

Using the xenon-133 inhalation method, we studied the age-related decline in regional cerebral blood flow, calculated as the initial slope index (ISI), in neurologically normal subjects without any risk factors for cerebral arteriosclerosis (154 men and 123 women), ranging in age from 19 to 88 years. The decline in the ISI was rapid in younger age groups and gradual in older age groups. The ISI was higher in women than in men older than 40 years. Using computed tomography, we studied the age-related decline in brain volume index (BVI; 100% X brain volume/cranial cavity volume) in neurologically normal subjects without any risk factors for cerebral arteriosclerosis (92 men and 49 women), ranging in age from 37 to 86 years. The decline in the BVI was gradual in younger age groups and rapid in older age groups. The BVI was higher in women than in men older than 60 years.

• Research Organization: Tohoku Univ., Sendai (Japan)
• OSTI ID: 7142797
• Journal Information: J. Am. Geriatr. Soc.; (United States), Journal Name: J. Am. Geriatr. Soc.; (United States) Vol. 36:4; ISSN JAGSA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
ARTERIOSCLEROSIS
ATROPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
SEX DEPENDENCE
TOMOGRAPHY
VASCULAR DISEASES
XENON 133
XENON ISOTOPES