A Radioisotope Method for Studying Cerebral Circulation
Journal Article
·
· Archives of Neurology
Time concentration curves, made with intravenously injected radioactive tracer and an externally placed detector over the head, were investigated as a method for evaluation of regional cerebral circulation. This concept can be utilized to obtain comparable values in different subjects proportional to monitored cerebral circulating blood volume. In 25 normal subjects between age 24 and 55, the values varied slightly, the mean value being 20 and the standard deviation 0.633. Normal subjects over 55 had lower and more variable values than the younger group, the mean value being 16.8 and the standard deviation 2.49. Lower values may reflect the tendency to decreased brain vascularity in the older age group. Inhalation of 5% CO2 in O2 produced no significant change in the values in normal subjects. However, Valsalva's maneuver produced a significant increase in normal subjects, and coughing produced the same change to a greater degree in 1 subject with cough syncope. Two of 12 patients with cerebrovascular disease had had intracerebral hemorrhages and gave significantly low values. The remaining 10 had cerebral arteriosclerosis resulting either in transient ischemic attacks or infarction. Their values did not vary significantly from those of normal subjects of similar age. Two patients with cerebral arteriovenous anomalies had high peaked curves, unique in shape and different from all the other curves. The procedure appears to be a relatively simple, innocuous way of ruling in or out the presence of cerebral arteriovenous anomalies in suspected cases.
- Research Organization:
- Originating Research Org. not identified
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-005711
- OSTI ID:
- 4768611
- Journal Information:
- Archives of Neurology, Journal Name: Archives of Neurology Journal Issue: 6 Vol. 5; ISSN 0003-9942
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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