Changes in hyperfrontality of cerebral blood flow and carbon dioxide reactivity with age

Journal Article · Fri Dec 01 04:00:00 EST 1989 · Stroke; (USA)

DOI:https://doi.org/10.1161/01.STR.20.12.1667· OSTI ID:5028949

Tsuda, Y; Hartmann, A ^[1]

---

1. Neurological Univ. Clinic, Bonn (Germany, F.R.)

We evaluated the topographic distributions of regional cerebral blood flow in 51 normal subjects (mean age 41 years) by the xenon-133 inhalation technique. Forty-five of these subjects were divided by age into young normals less than 30 years old (mean age 24 years), middle-aged normals 30-50 years old (mean age 40 years), and elderly normals greater than 50 years old (mean age 62 years); there were 15 subjects in each group. The distributions of vascular CO2 reactivity to hypocapnia were also evaluated in 20 of the normal subjects (mean age 34 years), including 11 younger normals less than 30 years old (mean age 24 years) and nine older (middle-aged or elderly) normals greater than or equal to 30 years old (mean age 45 years). The hyperfrontal distribution of regional cerebral blood flow observed in the young and middle-aged normals was not observed in the elderly normals. The hyperfrontal distribution of vascular CO2 reactivity observed in the younger normals was absent in the older normals. In addition, the correlation between regional cerebral blood flow and vascular CO2 reactivity observed in the younger normals was disturbed in the older normals. The data show a hyperfrontal distribution of regional cerebral blood flow in normal subjects that diminishes during the fifth and sixth decades, along with a distribution of vascular CO2 reactivity in younger normal subjects that is not homogeneous throughout the frontoparietal regions.

• OSTI ID: 5028949
• Journal Information: Stroke; (USA), Journal Name: Stroke; (USA) Vol. 20:12; ISSN SJCCA; ISSN 0039-2499
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
EVEN-ODD NUCLEI
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
NERVOUS SYSTEM
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PRIMATES
RADIOISOTOPES
VASCULAR DISEASES
VERTEBRATES
XENON 133
XENON ISOTOPES