Radiation leukemia in C57Bl/6 mice. I. Lack of serological evidence for the role of endogenous ecotropic viruses in pathogenesis

Journal Article · Tue Nov 30 23:00:00 EST 1976 · J. Exp. Med.; (United States)

DOI:https://doi.org/10.1084/jem.144.6.1391· OSTI ID:7142671

Ihle, J N; McEwan, R; Bengali, K

The humoral immune response against endogenous ecotropic murine leukemia viruses (MuLV) was examined in irradiated and control C57BL/6 mice. Control mice developed antibodies against MuLV slowly throughout life. In contrast, within 2 to 3 months after irradiation 90 percent of irradiated C57BL/6 mice had developed detectable antibodies against MuLV. The characteristics of this immune response, however, were identical in control and irradiated mice in terms of peak titers, specificity for endogenous ecotropic MuLV, and reactivity against the ecotropic viruses' glycoprotein. The incidence of lymphoma was comparable in mice that developed no immune response; developed an immune response only transiently after irradiation; or developed an immune response which persisted until death from lymphoma. Moreover, experimental conditions that alter the ability of irradiation to induce leukemia, such as age, dose, or bone marrow reconstitution did so without significantly altering either the rate of appearance of a humoral immune response to MuLV or its peak titers. The results, therefore, fail to demonstrate any seroepidemological relationship between endogenous ecotropic MuLV and radiation-induced leukemia.

• Research Organization: National Cancer Inst., Frederick, MD
• OSTI ID: 7142671
• Journal Information: J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 144:6; ISSN JEMEA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
HEMIC DISEASES
IMMUNE REACTIONS
LEUKEMIA
LYMPHOMAS
MAMMALS
MICE
MICROORGANISMS
NEOPLASMS
PARASITES
PATHOGENESIS
RADIATION EFFECTS
RADIOINDUCTION
RODENTS
VERTEBRATES
VIRUSES