Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Modification and inhibition of repair of potentially lethal x-ray damage by hyperthermia

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574345· OSTI ID:7141570
; ;
The effects of 43/sup 0/C hyperthermia on recovery from x-ray-induced potentially lethal damage were examined in plateau phase Chinese hamster cells. If heating preceded irradiation (''preheat''), the cell killing assayed immediately after the sequential treatments was greater than if the treatment order was reversed (''postheat''). Preheating for periods up to 45 min did not interfere with recovery from potentially lethal damage (as assayed by survival measurements of cells maintained in salt solution for the recovery period), although the kinetics were modified by the introduction of a slow component of recovery. On the other hand, postheating progressively slowed repair and 60 min at 43/sup 0/C completely inhibited it. The interaction of x irradiation and 43/sup 0/C hyperthermia was found to be maximum if the treatments followed each other with negligible time delay. The data indicate that an optimum sequence of 43/sup 0/C hyperthermia and x irradiation for radiotherapy would involve a short (approximately 15 min) preheating period, rapidly followed by x irradiation and then an immediate exposure to heat for a longer (45 to 60 min) period.
Research Organization:
Stanford Univ., CA
OSTI ID:
7141570
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 67:3; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Combined effects of x irradiation and hyperthermia (42 and 44/sup 0/C) on Chinese hamster V-79 cells in vitro
Journal Article · Sun Jul 01 00:00:00 EDT 1979 · Radiat. Res.; (United States) · OSTI ID:5686141
Interaction of hyperthermia and radiation in CHO cells: recovery kinetics
Journal Article · Tue Jun 01 00:00:00 EDT 1976 · Radiat. Res.; (United States) · OSTI ID:7356537
Mammalian cell survival response following irradiation with 4 MeV x rays or accelerated helium ions combined with hyperthermia
Journal Article · Tue Jun 01 00:00:00 EDT 1976 · Radiology; (United States) · OSTI ID:7364226

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY TEMPERATURE
CELL KILLING
ELECTROMAGNETIC RADIATION
HAMSTERS
HYPERTHERMIA
IONIZING RADIATIONS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RECOVERY
RODENTS
THERAPY
VERTEBRATES
X RADIATION